I have not noted any difference between brand versus generic. I did experience a significant difference in the potency effect when the medication was close to it's expiration date... I now clearly mark the bottle in use (I use a 3 month supply mail order plan.)

I don't know I always take generic I tried Ryatan Time release worked wonderful unfortunately too expensive so back to Time release worked wonderful unfortunately too expensive so back to Carbo/levadopa

I get mine thru the VA so I don't notice the difference because my meds are both

My husband can not use the generic sine met but he can use the generic Parcopa ODT. Don't know why but it just is.

I've used both, I prefer brand over generic. I feel better with the brand