Yes my husband who is 69 years old and has this disease for more than 25 years. Every Parkinsons medicine caused psychosis until he was is deathbed with Mirapex (trying to fix his car at 2 AM at night). I asked doctor Liberman on line and came to know what a dangerous med he was given. I had to request the doctors to withdraw that med. I took him to famous doctor's in three states no one told me that he needs antipsychotic med with Carbidopa. Finally ten years back when I researched and asked his neuro added Clozaril which I did not want because it destroys white blood cells. And I wrote to Doctor Liberman and he suggested Quitipine. That saved my life. He takes 100 mg. in the evening and 50 mg. in the morning. I can sleep and he can sleep at night now. So I have a strong notion doctor's because they have malpractice insurance don't care about you and me. So to save me I do a lot of research whenever there is a problem. Hope this will help you to get a good nights sleep.

things that crossed my mind.... PD can cause anxiety and depression. Could he be drinking alcohol without you knowing?

Confusion: Although neurodegeneration associated with Parkinson’s disease can cause confusion (especially in severe cases), confusion is also a recognized side effect of Sinemet treatment. The side effect of confusion resulting from Sinemet administration may be characterized by: brain fog (inability to think clearly), disorganized thinking, lack of focus, and memory problems (retrieval difficulties). Since confusion can interfere with ability to function in social and occupational settings, it should be considered an impairing side effect.

Certain individuals may find that confusion subsides as they adjust to ongoing administration of Carbidopa-Levodopa. Others may experience confusion as a side effect, regardless of the duration over which they’ve been taking Sinemet. If you feel extremely confused while taking Carbidopa-Levodopa, discuss possible ways to decrease this side effect with your doctor.

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How old is your husband.

I went to another doctor for an opinion. I was taking 2 sinemet 2 times a day.10-100 I wasn't getting better but was doing ok. The new dr. (a specialist) told me to put side those pills and take
25-100 4 times a day. I did that and the first couple of days it was bad, I fell 4 times,I couldn't stand up and was dizzy. Called the dr. and the receptionist took the message. He got back to me and said the dr. couldn't change the amount till I saw him. Well, my appointment was in 3 weeks, I decided that I would only take 1 pill 3 times a day. It was better but I still can't stand up and am back to the walker. I called again and said I had to speak to the Dr.....that was 4 days ago and he never called me. ......I am going back to the (Phone number can only be seen by the question and answer creators) times a day and am going to cancel my appt. with the specialist.