While it's a helpful supplement to the carbodopa/levodopa, in my husband it has triggered compulsive behavior. Requip, another dopamine agonist, had a kind of similar effect. He tried going off it several days, compensating by taking extra carbodopa. It wasn't enough, really, still stiffness, cramping.
Never use it
I couldn’t use Neupro either it irritated my skin. I am now on ropinirole it’s been 6 weeks no issues.
For the cramps try Magnesium tablets. Magnesium got rid of my cramps.
I take it from that response had problems too, sigh.
good question! I am having skin irritation issues with Neupro and would be interested in any guidance you get.