During my research and reading about Parkinsons that the best antidepressant was “Effexor”. It works differently with Parkinsons. Most antidepressants mellow you out but still keep you down. I spoke to my Neuro and she didn’t know it made a difference. What happens is it works more like Speed is suppose to work. She switched me over and sure enough I know have energy most days. Overall I feel more upbeat. Maybe it will work for you too. Good luck!

I have to take sertraline every lunchtime. I have Parkinson’s and other non related health issues that j have caused my left leg to drag. I have been a very active person with a full life. I’m now struggling just to manage my house I.don’t know what’s Parkinson’s or not anymore. I can go on forever as could we all. I was crying all the time when Not on the sertraline I am thinking more positively now and have tried a few new activities and how to do things easier. I am a lot happier and have even put on a little weight. Sorry to have rambled so long.

I take trazodone for antidepressants not severe, xanax for anxiety no side affects - i feel it also helps with mild stiffness.
Of course take C/L three times a day usually but experiment occasionally.

Thanks for the response. Do you take anything for Parkinson’s?

I was diagnosed with clinical depression 1997 and have been on Lexapro and Wellbutrin, I’m also on Trileptal for Bipolar. The combination of these seem to keep me in good shape. I do have days when the depression overwhelms me, if I get myself moving with some kind of activity I can push through but there’s times I have to just sit quietly. Keep your chin up, you’ve got this. Collette