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Parsitan For Tremors
A MyParkinsonsTeam Member asked a question 💭

Is anyone taking Parsitan for tremors? My neuro recommends it but, unfortunately, it's only sold in Canada. I was diagnosed 2 years ago with young onset PD and my only symptoms, so far, are tremors in my left arm and leg. I take selegiline and amantadine. Tried CBD oil, which hasn't really had much affect.

posted April 17, 2016
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A MyParkinsonsTeam Member

if you live in a state where it is legal you will find that besides cbd oil there are also different types of cannabis strains known as indica's and sativa's. talk to the staff at a dispencery they can help you make decisions according to your needs.

posted April 23, 2016
A MyParkinsonsTeam Member

Fortunately, I do live in a state where it's legal @A MyParkinsonsTeam Member. But I also have a medical marijuana card. Trying different ones to see which works best. Thanks for the info.

posted April 23, 2016
A MyParkinsonsTeam Member

@A MyParkinsonsTeam Member did your wife have tremors? I've tried 3 different CBD oils (and yes @A MyParkinsonsTeam Member it is from cannabis ). All 3 were tinctures and the 1st one had no THC and was 24% CBD. The 2nd one was 18mg CBD and 2mg THC. The third is 38mg CBD and 2mg THC. None of them really helped with the tremors. One other option I may try would be one that is a 1 to 1 ratio of CBD and THC.
My neuro tells me that parsitan would help with the tremors but it's still a synthetic drug. I'm hoping and praying to find a solution as natural as possible.

posted April 21, 2016 (edited)
A MyParkinsonsTeam Member

Hi AnnMarieP;I have had pd for 13 yrs. And it started in my left hand. Then in time it has just went on my left side. I have never heard of. Parsitan. But i have took and still take Carbadopa/Levadopa. It is the generic for Sinemet. I don't have any side effects with it .Except the longer you have it the more pills you take. But now I wouldn't take anything for them. They have been good for me. I also take Pramapoxile. Hope this helps Good Luck

posted April 18, 2016
A MyParkinsonsTeam Member

I agree with @A MyParkinsonsTeam Member totally... Alan

@A MyParkinsonsTeam Member pass on to your provider

Long-Term Safety of Levodopa Us

Despite proven effectiveness and wide use of levodopa, usually prescribed as Sinemet® (carbidopa-levodopa), to manage movement symptoms in PD, doubts have lingered over the drug’s long-term safety. Research published Oct 11, 2011 in the journal Neurology, scientists conclude that larger cumulative doses of levodopa, taken for years or decades, do not harm critical brain cells in people with Parkinson’s.

The long-term use of levodopa is associated with dyskinesia and “wearing-off” periods in between doses during which symptoms recur. Scientists debate whether these long term side effects are a result of Parkinson’s progression, or whether they are related to longer use of the medication.

Scientists at the University College of London led by Andrew J. Lees, M.D., reasoned that if levodopa is toxic to dopamine neurons, the more levodopa a person took during the course of Parkinson’s, the fewer dopamine neurons would remain in the brain at death. In new research, they studied brain tissue, retrieved from a brain bank, from 96 people who had died with Parkinson’s. Most of these people had late-stage Parkinson’s at the time of death, and had died, on average, at age 73 after living with Parkinson’s for about 15 years.

The researchers focused on two characteristics of the brain tissue: they counted the dopamine neurons remaining in an area of the brain called the substantia nigra, which is critical in coordinating body movements; and they measured the build-up of the protein alpha-synuclein (called Lewy bodies) in cells in the cortex and substantia nigra. Lewy bodies are a hallmark of Parkinson’s, thought to contribute to the death of dopamine neurons.

Results:
• No significant relationship was found between the total amount of levodopa taken and the loss of neurons & between the dose of levodopa and the accumulation of Lewy bodies.
• A subgroup of study participants, who had early onset Parkinson’s and longer exposure to levodopa, had not lost more dopamine neurons than others in the study.
•Three of the study participants had very high cumulative doses of levodopa, having taken the drug for up to 31 years. These participants had not lost more dopamine neurons than participants exposed to less levodopa.

What Does it Mean?

The new research supports other evidence that levodopa does not hasten the progression of Parkinson’s, but affirms the benefits of levodopa for managing symptoms far outweigh the risk of harm. There is no doubt that levodopa is the best available medication for Parkinson’s, and shown to substantially prolong the life expectancy of people affected by PD.

http://www.pdf.org/en/science_news/release/pr_(Phone number can only be seen by the question and answer creators)

posted April 19, 2016 (edited)

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