I take caribidopa/levidopa 25/100 1 and a half tabs 4 times a day. and it can take up to a month for it to start working. at least it did for me. i still fall and have rigidity, im not sure how i would feel with out it anymore... good luck to you! i start mine 8am, 12pm, 4pm, 8pm nothing in the middle of the night

I take Carbidopa/Levidopa 25-100 2 pills 3 time per day. 1 is standard release, and one extended release. I also take Amantadine 100mg, and Selegiline 5mg both twice a day. These two are to extend the durtation of the effects of the dopamine, and to smooth out the peeks and valleys from the dopamine.

I take 125/100 every 3 hours (6,9,12,3,6,9) and supplement them with 3 125/100 ERs. That's extended release -- they release the medication slower and it lasts longer. It was my main problem after being diagnosed and it probably took a year to get me stable. Occasionally I have your problem but my bad time only lasts about 15 minutes. I can handle that. Everybody reacts differently so you have to work with your doctor. Hang in there and don't get discouraged. Lots of hugs... .

If it's wearing off too quickly even need to either up your dose or ask your medical team to add entacapone or stavelo to your medication these are lengthing drugs they make your levodopa last longer generally about 6 hours per dosage.