Hi Monica - he takes 25 mg of seroquel. Definitely helps with sleeping and the anxiety has gotten better but not 100%. At first it made him very groggy but now he's doing better. He was so restless at night - he also has a sleeping disorder with the Parkinsons where he has loud dreams and sometimes has punched me! so I'm glad the seroquel helps. He may need to go up a dose though. I will also say it took a couple weeks for it to help. Usually takes 2-3 weeks. Also takes melatonin at night. The problem we're trying to figure out now is why he continues to have tremors even after his Rytary - we think it's too close to a high protein or fatty meal. Happened today even though he waited an hr to take his meds. As to your Mom, I would also talk to the pharmacist because they can help you understand if the medication is causing the agitation and reality issues. I read on some blogs that some people take as much as 600 mg!! Good luck and keep in touch. - Nancy a.k.a RainbowMom..

My mom was perscribed 2 tablets of 195mg 3-4 times a day. Then was reduced to 2 tablets of 145mg 3-4 times a day. A year later she developed delusions, excessive thinking aloud of random thoughts, and confusion. Looking into doses I wonder if she was perscribed too much. She usually took 25/100mg of sinemet 4 times a day. I don't know the weird behaviors are a result of too much medicine or just the disease. She started taking seroquel 50mg at night a week ago. No change yet. Just keep her calm a little on clonazapam.

Hi Nancy,

I’ve been on Rytary for nearly 2 years and thankfully have never experienced your husbands symptoms. There is reason to believe the symptoms are a side effect of the Rytary-here is an excerpt from the rxlist website:

“There is an increased risk for hallucinations and psychosis in patients taking RYTARY. In a controlled clinical trial in patients with advanced Parkinson's disease, 9/201 (4%) of RYTARY-treated patients reported hallucinations or psychosis compared to 2/192 (1%) of oral immediate-release carbidopalevodopa- treated patients.”

https://www.rxlist.com/rytary-drug.htm#P

I am wondering, since Rytary is basically extended release Sinemet, could your husband try going back to Sinemet for a while, just to see if there is a correlation with the Rytary and psychosis?

My husband was having psychotic breaks a couple of years ago. The neurologist said it was part of Parkinson's. He referred us to a psychologist that had knowledge of Parkinson's. He put him on Seroquel and it has helped a lot.

thanks for your feedback. My husband's dr doesn't feel that way. I am going to talk to his psych dr. to see what she thinks of the new Rx neurologist prescribed.