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Real members of MyParkinsonsTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
November 18, 2025
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MyParkinsonsTeam

Can carbidopa-levodopa (C/L) cause upset stomach?

Yes, gastrointestinal issues are common with Parkinson's disease and can be affected by medications like carbidopa-levodopa. Many people with Parkinson's experience digestive symptoms including:

- Nausea
- Vomiting
- Bloating
- Constipation
- Gastroparesis (delayed stomach Show Full Answer

Can carbidopa-levodopa (C/L) cause upset stomach?

Yes, gastrointestinal issues are common with Parkinson's disease and can be affected by medications like carbidopa-levodopa. Many people with Parkinson's experience digestive symptoms including:

- Nausea
- Vomiting
- Bloating
- Constipation
- Gastroparesis (delayed stomach emptying)

These digestive symptoms can occur both from Parkinson's itself (which affects the autonomic nervous system controlling digestive muscles) and can impact how well carbidopa-levodopa is absorbed in your stomach and intestines.

If you're experiencing upset stomach with your current dosing schedule, it's important to talk with your doctor. They may be able to adjust your dosing, timing, or suggest ways to take the medication that might reduce stomach discomfort. Don't stop or change your medication without consulting your healthcare provider first.

November 18, 2025
A MyParkinsonsTeam Member

Yes, it can. Taking your pills with food, instead of on an empty stomach, may help. Crackers or fruit or something that isn't protein is best.

November 19, 2025

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