Mirapex (Pramipexole dihydrochloride) for Parkinson's disease

The Mirapex brand name has been discontinued in the U.S. Generic alternatives may be available.

Overview

Mirapex is a prescription drug approved by the U.S. Food and Drug Administration (FDA) in 1997 to treat motor symptoms of Parkinson’s disease. Mirapex is also referred to by its drug name, pramipexole dihydrochloride. Mirapex is not suitable for people with a major psychotic disorder or those who have previously shown hypersensitivity to pramipexole. Mirapex must be used with caution in people with high or low blood pressure, asthma, schizophrenia, sleep disorders, heart problems, kidney problems, or a history of alcohol addiction. Mirapex may not be appropriate for women who are pregnant or breastfeeding. Mirapex is a member of a class of drugs called dopamine agonists. Mirapex is believed to work by imitating the action of dopamine in the brain.

How do I take it?

Mirapex is taken orally as a tablet three times a day. Mirapex may be taken with or without food. Taking Mirapex with food may help prevent stomach upset. Take Mirapex at the same times each day. Do not drink alcohol while you are taking Mirapex. Alcohol can increase the intensity of some side effects. Avoid driving or operating machinery while using Mirapex. Do not stop using Mirapex suddenly. If you decide to stop using Mirapex, form a plan with your doctor for gradually tapering off your dosage to avoid withdrawal symptoms. Always follow your doctor’s instructions exactly when taking Mirapex.

Side effects

Common side effects of Mirapex in those not taking levodopa include nausea, dizziness, drowsiness, insomnia, constipation, weakness, and hallucinations. In those taking levodopa with Mirapex, common side effects include dizziness upon standing, abnormal movements, insomnia, hallucinations, accidental injury, dream abnormalities, confusion, constipation, weakness, drowsiness, walking abnormality, dry mouth, memory loss, and increased frequency of urination. Tell your doctor if these side effects become worse. Inform your doctor immediately if you experience a fast, pounding, or uneven heartbeat; cramping or rigid muscles; fever; chest pain; agitation; hallucinations; impulsive or psychotic behavior; slurred speech; or seizures while taking Mirapex. Rarely, dopamine agonists such as Mirapex may contribute to the development of serious lung or heart-valve problems, including pleural effusion, retroperitoneal fibrosis, or cardiac valvulopathy. These conditions may or may not resolve after you stop taking the drug.

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Mirapex — RxList