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Zelapar is a prescription drug approved by the Food and Drug Administration (FDA) in 1989 to treat motor symptoms in people with Parkinson’s Disease. Zelapar may be prescribed as a monotherapy to people with early Parkinson’s Disease, or as an adjunctive (add-on) treatment in those who are taking Levodopa/Carbidopa and experiencing reductions in its effectiveness. Zelapar may be referred to by its drug name, Selegiline. Selegiline is also sold under the brand name Eldepryl.

Zelapar is not suitable for use in people who have previously shown hypersensitivity to the drug or its inactive ingredients. Zelapar must be used with caution in people with phenylketonuria or liver or kidney disease. Zelapar may not be appropriate for women who are pregnant or breastfeeding.

Zelapar is a member of a class of antidepressant drugs called monoamine oxidase inhibitors (MAOIs). In cases of Parkinson’s Disease, Zelapar is believed to work by preventing the breakdown of dopamine in the brain, thereby increasing the amount of dopamine available.

Some medications are available both as generic and branded products. Although generic and branded formulations of a drug contain the same active ingredients at the same concentrations, your body may react differently to different formulations. Check with your doctor before switching between drug brands or between generic and branded drugs.

How do I take it?
Zelapar is taken orally as a disintegrating tablet. Take Zelapar once daily on an empty stomach, before breakfast. Do not eat or drink five minutes before or after taking Zelapar.

Do not stop using Zelapar suddenly. If you decide to stop using Zelapar, form a plan with your doctor for gradually tapering off your dosage to avoid withdrawal symptoms.

Always follow your doctor’s instructions exactly when taking Zelapar.

Multiple clinical studies have established that Selegiline (Zelapar) is effective at treating motor symptoms and reducing disability in those with Parkinson’s Disease. Taking Selegiline can help delay the need for treatment with Levodopa/Carbidopa and reduce the dose and frequency of the latter medication.

Side effects
Common side effects of Zelapar include drowsiness, dizziness, dry mouth, nausea, vomiting, stomach pain, gas, diarrhea, constipation, trouble sleeping, unusual dreams, back or leg pain, or rash. If you are taking Zelapar disintegrating tablets, you may develop mouth sores. Tell your doctor if these side effects become worse.

Inform your doctor immediately if you experience chest pain, fast or pounding heartbeat, trouble breathing, hallucinations, stiff or painful neck, unusual shaking or body movements, severe headache, or sudden, severe nausea or vomiting while taking Zelapar.

Many drugs can cause allergic reactions that in the most serious cases, can result in death. Seek immediate medical help if you experience signs of a severe allergic reaction such as hives, difficulty breathing, or swelling in the face, throat, eyes, lips, or tongue.

Zelapar (Selegiline) for Parkinson's disease Questions

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