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A MyParkinsonsTeam Member asked a question 💭
Calexico, CA

Some time ago a scan was done of my brain and it turned out that, while in most people the folds of the brain press against one another, in my brain there is space between the folds. Does anyone know if this is pathological or a normal variation in brain structure.

April 12, 2016
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A MyParkinsonsTeam Member

Your question leaves me with lots of questions, but no answer. More information is needed to give you an answer.
"Some time ago a scan was done of my brain"
Why was the scan done? Who read it? Did they give a name to the diagnosis ? Are there symptoms related to this condition ? Did you always have this or is it new?

polymicrogyria --- https://ghr.nlm.nih.gov/condition/polymicrogyria

Some of the more common brain fold disorders..

Anencephaly (Q00.0)
Colpocephaly (ICD10 unknown)
Holoprosencephaly (Q04.2)
Ethmocephaly (ICD10 unknown)
Hydranencephaly (Q04.3)
Iniencephaly (Q00.2)
Lissencephaly (Q04.3)
Megalencephaly (Q04.5)
Microcephaly (Q02)
Porencephaly (Q04.6)
Schizencephaly (Q04.6)

April 13, 2016
A MyParkinsonsTeam Member

@Robertgoeckeolce I don't have any knowledge of this. But willing to learn.

April 14, 2016
A MyParkinsonsTeam Member

CONT. BRAIN FOLDS. POST 2.
The size and extent of folding of the mammalian cerebral cortex are important factors that influence a species' cognitive abilities and sensorimotor skills. Studies in various animal models and in humans have provided insight into the mechanisms that regulate cortical growth and folding. Both protein-coding genes and microRNAs control cortical size, and recent progress in characterizing basal progenitor cells and the genes that regulate their proliferation has contributed to our understanding of cortical folding. Neurological disorders linked to disruptions in cortical growth and folding have been associated with novel neurogenetic mechanisms and aberrant signalling pathways, and these findings have changed concepts of brain evolution and may lead to new medical treatments.

MY SUMMARY: From what I have gathered here, is the gaps between brain folds are there to accomodate brain size as it fills the brain space. Has this caused any health or cognitive issues, or pressure on the brain space for you? There is a lot of scientific "riff-raff" found in this answer but it all seemed to lead to the summary. Perhaps others will answer and help you get a clearer understanding of your question. Sterling
.

April 13, 2016
A MyParkinsonsTeam Member

@A MyParkinsonsTeam Member

BRAN FOLDS
this wrinkling — called gyrification — might occur in brain development. The researchers theorized that the folds form because the outside of the brain grows quicker than the inside of the brain, causing it to fold inward. During evolution, the mammalian cerebral cortex has expanded disproportionately to brain volume. As a consequence, most mammals with large brains have profusely convoluted cortices. The human cortex is a good example of this trend, however, given the large variability in human brain size, it is not clear how cortical folding varies from the smallest to the largest brains. We analyzed cortical folding in a large cohort of human subjects exhibiting a 1.7-fold variation in brain volume. We show that the same disproportionate increase of cortical surface relative to brain volume observed across species can be also observed across human brains: the largest brains can have up to 20% more surface than a scaled-up small brain. We introduce next a novel local measure of cortical folding, and we show that the correlation between cortical folding and size varies along a rostro-caudal gradient, being especially significant in the prefrontal cortex. The expansion of the cerebral cortex, and in particular that of its prefrontal region, is a major evolutionary landmark in the emergence of human cognition. Our results suggest that this may be, at least in part, a natural outcome of increasing brain size.

During evolution, the mammalian cerebral cortex has expanded disproportionately to brain volume. As a consequence, most mammals with large brains have profusely convoluted cortices. The human cortex is a good example of this trend, however, given the large variability in human brain size, it is not clear how cortical folding varies from the smallest to the largest brains. We analyzed cortical folding in a large cohort of human subjects exhibiting a 1.7-fold variation in brain volume. We show that the same disproportionate increase of cortical surface relative to brain volume observed across species can be also observed across human brains: the largest brains can have up to 20% more surface than a scaled-up small brain. We introduce next a novel local measure of cortical folding, and we show that the correlation between cortical folding and size varies along a rostro-caudal gradient, being especially significant in the prefrontal cortex. The expansion of the cerebral cortex, and in particular that of its prefrontal region, is a major evolutionary landmark in the emergence of human cognition. Our results suggest that this may be, at least in part, a natural outcome of increasing brain size. CONT. POST 2

April 13, 2016
A MyParkinsonsTeam Member

Sorry can't help. I know nothing sbout it.

April 13, 2016

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