My spouse has Parkinson's and is presently on Requip. Levodopa did not work out. I recently saw an article on the internet about how SSRI antidepressants could be a conflict. He also takes Zoloft 25mg, which is a low dose, and has been on it for about 3 years before his diagnosis. I don't always trust what is part of WWW, so thought I should go to a source I do trust. This site and its members. Let me know if you know of anything or a trustworthy link I could review. God bless!!!