INTERNATIONAL PARKINSON AND MOVEMENT DISORDER SOCIETY

Infusion Therapies for Parkinson's Disease: Essential Facts for Patients
What Is the Role of Medication in Parkinson’s Disease?

Patients with PD do not have enough of the chemical dopamine in the brain. Medication can help PD symptoms. Most medicines are taken by mouth several times each day. When you first start taking your PD medicines, the benefits usually last throughout the whole day; however, as PD progresses, you may notice that the medicine’s benefits don’t last to the next dose. This is called “wearing off.” When “OFF”, PD symptoms such as tremor, slowness and difficulty walking may come back. When the medicine kicks back in, “ON”, the symptoms improve. This results in taking medicine more frequently and having less control over your symptoms.
 
What Are Infusion Therapies for PD?

Infusion therapies are treatments either through a small needle inserted under the skin or through a tube (catheter) inserted into your small intestine. This provides a continuous flow of drugs throughout the day. Levodopa and apomorphine are two common infusion therapy drugs that address the lack of dopamine in the brain.

Levodopa: This drug is transformed into dopamine in the brain. This is the most commonly used pill for PD, and now it can be infused into the intestine as a gel called [[treatment:levodopa/carbidopa:55d534f51fcaa397470006dd]] intestinal gel (LCIG) to reduce OFF periods.
Apomorphine: This drug, a dopamine agonist, acts on brain cells like dopamine does. It is infused under the skin either as a single injection or continuous infusion. It helps reduce OFF periods.

Both LCIG and apomorphine are stored in an external portable pump that is connected to a tube. The LCIG pump tube is connected to a tube that delivers levodopa into the intestine. The apomorphine pump is attached to a thin needle inserted under the skin with an adhesive to keep it in place.
 
Why Use Infusion Therapies?

When you suffer from “wearing off”, your brain cells don’t absorb levodopa and store dopamine as well. As a result, you can’t control your symptoms and you need to take the drug more often during the day.
 
Who Should Consider This Treatment?

Infusion therapies are recommended if oral medication helps you but you have developed “wearing off” and/or dyskinesias (involuntary movements that happen with too much medication). Most patients have usually tried a few different oral and/or patch medications before deciding to start infusion therapies.

Patients generally start infusion therapy either in a hospital or sometimes at an outpatient clinic.
 
Hope this article is of help for you

You Parkinson's thank you Parkinson's movement disorder society!! For your message about the infusion I really appreciate it it was very good!!
For me I will talk to my doctor about
The patch for sure, because I have to
Take so many medicine's so once again 💗 I thank you very much 🥰.
Julie Olson 2 😊 hug 🫂.

Merry Christmas from Santa and Mrs. Claus.

@ Dw2 Thank you for your post about infusion!! Wow 😲 it cost a lot of money 💰. Julie Olson 2 😊 hug 🫂 for you.

I wasn’t aware of the patch. I also take many other medications.