Parkinson's Gene Therapy Wires New Brain Circuits | MyParkinsonsTeam

Connect with others who understand.

sign up Log in
Resources
About MyParkinsonsTeam
Powered By

Parkinson's Gene Therapy Wires New Brain Circuits

Posted on February 14, 2019


By Amy Norton, HealthDay Reporter

WEDNESDAY, Nov. 28, 2018 (HealthDay News) -- An experimental gene therapy for Parkinson's disease seems to work by rewiring key areas of the brain, a new study finds.

The researchers focused on 15 Parkinson's patients who, in an earlier trial, had received so-called GAD gene therapy. GAD is an enzyme that spurs the production of a brain chemical involved in movement control.


In the previous trial, patients had shown improvements in their movement problems after receiving infusions of the GAD gene into the brain.

What hadn't been clear was precisely why, said researcher Dr. David Eidelberg, who directs the Center for Neurosciences at the Feinstein Institute for Medical Research, in Manhasset, N.Y.

So for the new study, Eidelberg's team examined specialized brain scans from 15 of the trial patients. The investigators found an unexpected answer: The gene therapy did not change the abnormal brain circuitry that marks Parkinson's disease.

Instead, it essentially rewired a small area of the brain, to partially compensate for the faulty circuitry.

"It created its own set of circuits," Eidelberg explained. "The disease circuitry continues -- so this is not a cure."

Still, he said, the gene therapy seems to spur new brain connections that can benefit people with Parkinson's.

Parkinson's disease affects nearly 1 million people in the United States alone, according to the Parkinson's Foundation.


The root cause is unclear, but as the disease progresses, the brain loses cells that produce dopamine -- a chemical that regulates movement. As a result, people suffer symptoms like tremors, stiff limbs, and balance and coordination problems that gradually worsen over time.

There are treatments to lessen those symptoms, including medications that boost dopamine levels or mimic the actions of dopamine. Another option for some patients is deep brain stimulation (DBS), where electrodes are implanted in a specific brain area to deliver continuous electrical pulses. It's thought to help by suppressing abnormal electrical activity.

GAD gene therapy is done by inserting the gene into an inactivated cold virus. That viral "vector" is infused into a specific brain area called the subthalamic nucleus -- which is one of the brain regions targeted in DBS treatment.

Originally, Eidelberg added, researchers thought the gene therapy would work in a "DBS-like" way.
But based on the new findings, that's not the case.

Dr. Michael Okun is
medical director of the Parkinson's Foundation. He called the study "fascinating."

"It showed that GAD gene therapy, unlike subthalamic nucleus DBS, did not change the expected Parkinson's disease brain network," Okun said. "Instead, it co-opted adjacent non-motor pathways."

Why does that matter? One reason, according to Okun, is that it offers an "important lesson" for the gene therapy field going forward.

Researchers cannot make assumptions about a therapy's "mechanism of action," he said, based on the brain area it targets.

Eidelberg made another point: In future studies, researchers could use brain imaging to be sure that patients' symptom improvements are due to a true effect of the gene therapy -- rather than a "placebo effect."

In the original trial, which involved a few dozen Parkinson's patients, some were randomly assigned to receive GAD gene infusions. The rest underwent a "sham" procedure for comparison.

Over six months, both groups showed improvements in movement symptoms like stiffness and tremor. But the gene therapy group saw greater gains.

"It wasn't a slam dunk," Eidelberg stressed. "But they were doing better. And that persisted to the one-year mark."

With any such therapy, there is a theoretical concern that the infused gene will have unintended effects.

"What we've seen is that this gene stays put," Eidelberg said. "It doesn't percolate all over the brain."

In the original trial, there were no red flags, according to the researchers. The most common side effects were temporary headaches and nausea.


Various research teams are looking at different approaches to gene therapy for Parkinson's. The hope, Eidelberg said, is to develop additional options that work for at least some patients -- possibly freeing them from taking daily medications.

At this point, he noted, there is "a lot of interest" in doing a larger, later-stage trial of the GAD therapy. But none has begun yet.

The current study was funded by Neurologix Inc., the company that developed the gene therapy.
SOURCES: David Eidelberg, M.D., director, Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, N.Y.; Michael Okun, M.D., medical director, Parkinson's Foundation, Miami; Nov. 28, 2018, Science Translational Medicine
Copyright © 2018 All rights reserved.

Here are some questions and conversations from MyParkinsonsTeam:

"My neurologist has suggested that I research DBS and consider it for the near future. Is it worth it?"

"Let's talk DBS - lots of info on the actual procedure out there, but very little on recovery. Can't wait to hear your answers!"


Have you participated in clinical trials for Parkinson's treatments?
Share your experience in the comments below or directly onMyParkinsonsTeam.

Posted on February 14, 2019
All updates must be accompanied by text or a picture.

Become a Subscriber

Get the latest articles about Parkinson's disease sent to your inbox.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Recent Articles

Welcome to MyParkinsonsTeam — the place to connect with others living with Parkinson's disease. ...

Getting Started on MyParkinsonsTeam (VIDEO)

Welcome to MyParkinsonsTeam — the place to connect with others living with Parkinson's disease. ...
It’s natural to be afraid of the side effects of the COVID-19 vaccine. However, the risks of gett...

Do COVID-19 Vaccines Worsen Parkinson’s Symptoms? What We Currently Know

It’s natural to be afraid of the side effects of the COVID-19 vaccine. However, the risks of gett...
People with Parkinson’s disease may develop a symptom called hypomimia, which is a loss or reduct...

Facial Masking (Hypomimia) With Parkinson’s Disease: Causes and Management

People with Parkinson’s disease may develop a symptom called hypomimia, which is a loss or reduct...
In a survey of caregivers on MyParkinsonsTeam, 88 percent reported feeling stressed watching thei...

Survey Results: Stresses and Rewards of Parkinson’s Caregiving

In a survey of caregivers on MyParkinsonsTeam, 88 percent reported feeling stressed watching thei...
Your body needs just the right balance of vitamins and minerals to function properly. When you’re...

Magnesium and Parkinson’s Disease: Are Supplements Beneficial?

Your body needs just the right balance of vitamins and minerals to function properly. When you’re...
Both Parkinson’s disease and Huntington’s disease are progressive neurodegenerative disorders tha...

Parkinson’s vs. Huntington’s Disease: What’s the Difference?

Both Parkinson’s disease and Huntington’s disease are progressive neurodegenerative disorders tha...
MyParkinsonsTeam My Parkinson's disease Team

Thank you for subscribing!

Become a member to get even more:

sign up for free

close