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A MyParkinsonsTeam Member asked a question 💭
Gloucester Point, VA

I've noticed that it seems shorter duration of effectiveness between doses doc has me on extended 9 am and 9 pm then he added lower doses at 1pm and 5 pm but it seems after about 2 hours I'm miserable and shaking again!

December 16, 2025
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A MyParkinsonsTeam Member

Russell6,
Merry Christmas to all. I am sorry I have not been on board recently as sold our house and am moving again to a rental space for now. My hub just got his dose of Levo/dopa just got increased and finds it extremely difficult to fit the doses in every 6 hours. And his hands are still shaking. Really having problems walking now just coming up stairs etc. Has to sit down a lot. Anyways, thankful he is still above ground. On that note should tell all of my friends posted under me I will not be able to reach out to everyone at this time with having to move in the next few days. Terrible time to be moving. Oh well, it always could be worse. Wishing you all a Happy New Year's. Take care, God Bless! Colleen😊🤗☺️🎊💗

December 30, 2025
A MyParkinsonsTeam Member

Crexont addresses dosage with timed-release caps, so far, much more effective than earlier pills. As Terry says, it varies, probably due to such variables as stature, weight, age and probably the weather. Unfortunately, we're stuck with the 'one-size-fits-all' approach to medicine--unless, of course, you're rich.

December 19, 2025
A MyParkinsonsTeam Member

It varies.

December 17, 2025
A MyParkinsonsTeam Member

I take 2 25/100mg every 3 hours and Pramipexole 0.5 mil 3 times a day

December 16, 2025
MyParkinsonsTeam

How long does [[treatment:levodopa/carbidopa:55d534f51fcaa397470006dd]] remain effective?

It sounds like you're experiencing "wearing off," which is the most common type of motor fluctuation in Parkinson's. This happens when medication effectiveness decreases before your next scheduled dose.

As Parkinson's progresses, the Show Full Answer

How long does [[treatment:levodopa/carbidopa:55d534f51fcaa397470006dd]] remain effective?

It sounds like you're experiencing "wearing off," which is the most common type of motor fluctuation in Parkinson's. This happens when medication effectiveness decreases before your next scheduled dose.

As Parkinson's progresses, the brain loses more dopamine-producing cells and can't store the medication as effectively as before. This makes the drug's effect last for shorter periods. Additionally, delayed gastric emptying can reduce how much medication gets absorbed into your bloodstream.

The timing you're describing—feeling symptoms return after about 2 hours—is actually when levodopa levels peak in your blood and then start declining. This is a recognized pattern that many people experience. What can help manage this?

Your doctor has several options to improve your symptom control:

* Adjusting the dose or timing of your levodopa
* Prescribing smaller, more frequent doses to keep levels steadier
* Switching to different formulations like long-acting or controlled-release versions
* Adding medications that help manage "off periods," such as COMT inhibitors, which prevent levodopa breakdown and extend its effectiveness

Keep a diary tracking when you take your medication and when symptoms return. This information helps your doctor fine-tune your treatment plan. A MyParkinsonsTeam member shared: "I try to notice small changes and write them down in a journal with date, time, frequency, and what happened, to share with my doctor."

December 16, 2025

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