MyParkinsonsTeam

The honest answer is that for most people, the exact cause of Parkinson's is still unknown. Scientists believe it's likely a combination of genetic and environmental factors working together — think of it as nature meeting nurture.

Here's what researchers have identified so far: What happens in the brain
- Parkinson's is Show Full Answer

The honest answer is that for most people, the exact cause of Parkinson's is still unknown. Scientists believe it's likely a combination of genetic and environmental factors working together — think of it as nature meeting nurture.

Here's what researchers have identified so far: What happens in the brain:
- Parkinson's is linked to the loss of dopamine-producing cells in a part of the brain called the substantia nigra
- Without enough dopamine, the brain struggles to coordinate movement properly
- Symptoms like tremors and slow movement typically appear when dopamine levels drop to about half of normal

Genetic factors:
- Around 10–15% of cases are thought to be entirely genetic
- About 85% of cases are "sporadic," meaning no clear genetic cause is found
- Some genes may make it harder for the brain to clear out toxins

Environmental factors:
- Exposure to pesticides and herbicides has been linked to higher risk
- Traumatic brain injury (TBI) may increase risk significantly
- Air pollution is being studied as a possible factor
- Diet may also play a role — deficiencies in Vitamin D or B12, and diets high in saturated fat, are being explored

Other risk factors:
- Age is the biggest factor — most people are diagnosed after 60
- Men are 1.5 times more likely than women to develop Parkinson's
- Certain medications, like antipsychotics, can trigger Parkinson's-like symptoms It's worth having a conversation with your neurologist about your personal risk factors, especially if there's a family history of Parkinson's — genetic testing may be an option worth exploring.

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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