I was put on Entacapone fairly recently, starting with 200 mg once a day and gradually working up to 200 mg four times a day. I was violently sick the first few weeks and even if I hadn't eaten anything and so had nothing to bring up I still suffered from violent retching with it! I managed to get up to the twice day but then was so ill that my GP actually made an unrequested house call - I thought I must really be on the way out then! I was all for giving it up and my GP agreed with me but the Consultant wanted me to keep trying so I did and eventually started to adapt to it. I now have it 4 times a day and have been able to reduce some of the Madopar. In terms of withdrawal I suffer from this about half an hour before the next dose but that's only if I have been sensible and not pushed myself too much in my "on" time. I now feel that it WAS worth persisting with it as it does seem to keep me on an even keel a bit longer.

Hi James when I've gone off it feels like I'm in a dream and in that dream I'm watching what's going on in front of me I can't see me because I'm watching it through my eyes it's the most horrible Sensation going and everything moves in front of me in slow motion.

hI James,, good solid attitude that you have is going to assist you in the long haul to win this war.. Keep your head up// take care rick

Hi Sally... life is good... i am also on carbo/levi and ropinrole plus gabapentin for restless leg.
Been 22yrs since dx. I'm thankful for meds and
research and for those that volunteer to do drug trials. We're winning the battle but not the war. "One day at a time"

I take all the above mentioned drugs.- the generic version, have for years now. Good days and bad days. I get dehydrated very easily and totally eliminates the effectiveness of my drugs. I live in the desert (110') today. Been doing the parkie cha cha now for 18 years. I am 65. Had some trouble lately with my shoulder (fell down some stairs) and DID NOT BREAK a bone. I am so lucky. When its cool and all my limbs are working I play tennis and i f not I ride bikes swim and take my sweet dog for fast walks. Gonna try Rock Steady Boxing in September. Take care Good Day wished for you .