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Real members of MyParkinsonsTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyParkinsonsTeam Member asked a question 💭
Fort Mill, SC

I take Rytary 247 five times a day and it is no longer enough so my neurologist added Sinemet to take as needed when "Off"

September 4, 2025
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A MyParkinsonsTeam Member

Rotary works great for me

September 4, 2025
A MyParkinsonsTeam Member

I could not tolerate Rotary so stopped taking it.

September 4, 2025
MyParkinsonsTeam

Yes, many people with Parkinson's take combinations of medications to manage their "off" periods. Both Rytary and Sinemet are different formulations of [[treatment:levodopa/carbidopa:55d534f51fcaa397470006dd]], which is a standard treatment for Parkinson's disease symptoms.

Members of MyParkinsonsTeam often report Show Full Answer

Yes, many people with Parkinson's take combinations of medications to manage their "off" periods. Both Rytary and Sinemet are different formulations of [[treatment:levodopa/carbidopa:55d534f51fcaa397470006dd]], which is a standard treatment for Parkinson's disease symptoms.

Members of MyParkinsonsTeam often report experiencing "off" episodes where their medication wears off, leading to symptoms like:
• Difficulty with walking and balance
• Increased tremors
• Muscle stiffness
• Fatigue
• Speech difficulties When levodopa medications become less effective over time, doctors may adjust treatment plans by adding additional medications or changing dosages. Using Sinemet as a rescue medication during "off" periods is one strategy doctors may recommend. There are also other options available, such as Inbrija (an inhaled form of levodopa) for quick relief during sudden "off" periods.

Always work closely with your neurologist to find the right combination and timing of medications that works best for your specific situation.

September 4, 2025

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A MyParkinsonsTeam Member asked a question 💭
Independence, MO