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Real members of MyParkinsonsTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
October 20, 2025
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Deep brain stimulation (DBS) is a surgical procedure that can help control motor symptoms and reduce the amount of levodopa needed. The procedure involves placing electrodes in movement-controlling areas of the brain and implanting a small impulse generator in a separate surgery.

Going off levodopa before DBS can be Show Full Answer

Deep brain stimulation (DBS) is a surgical procedure that can help control motor symptoms and reduce the amount of levodopa needed. The procedure involves placing electrodes in movement-controlling areas of the brain and implanting a small impulse generator in a separate surgery.

Going off levodopa before DBS can be challenging. Many MyParkinsonsTeam members report that medication effects typically wear off within 2-3 hours of taking a dose, with symptoms becoming more noticeable in the afternoon and evening. Factors like stress, anxiety, fatigue, and temperature changes can make symptoms more pronounced during off periods. To manage the transition period before surgery, consider:
• Working closely with your neurologist to develop a specific plan for reducing medication
• Planning the medication break during overnight hours when possible
• Minimizing stress and maintaining a comfortable environment
• Having support from family/caregivers during this time
• Understanding that temporary symptom increases are normal during this period

Remember to follow your surgical team's specific instructions, as requirements may vary between medical centers.

October 20, 2025

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