Is dementia hereditary in Parkinson's disease?
The relationship between genetics and Parkinson's-related dementia is complex. While Parkinson's itself has a genetic component in about 10-15% of cases, the dementia that can develop later isn't strongly tied to heredity in most situations.
Here's what research shows about Show Full Answer
Is dementia hereditary in Parkinson's disease?
The relationship between genetics and Parkinson's-related dementia is complex. While Parkinson's itself has a genetic component in about 10-15% of cases, the dementia that can develop later isn't strongly tied to heredity in most situations.
Here's what research shows about genetic factors:
- Most people with Parkinson's dementia don't have it due to inherited genes
- Certain genes like SNCA and LRRK2 are associated with Parkinson's and related dementia
- The APOE ε4 variant is linked to dementia with Lewy bodies, but not specifically to Parkinson's dementia
It's worth noting that about 75% of people who live with Parkinson's for at least 10 years may develop some form of dementia. Since your mom developed dementia in her early nineties after having Parkinson's, this progression isn't unusual.
Age is actually the most significant risk factor - both for developing Parkinson's and for developing dementia later. Your mom's age when dementia appeared suggests it was more related to the natural progression of her Parkinson's rather than a hereditary factor.
If you're concerned about your own risk, discussing your family history with your doctor can help. Genetic testing is available, though having a family history doesn't mean you'll necessarily develop either condition.
November 2, 2025
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