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A MyParkinsonsTeam Member asked a question 💭
Gloucester Point, VA

Does anyone here take entacapone? My neurologist prescribed this and I want to know what to expect? Does anyone know,?

May 4
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A MyParkinsonsTeam Member

I have been taking entacapone for several years with no ill effects. Hard to sy if it helps or not with so many other meds in the mix😀👍

May 5
A MyParkinsonsTeam Member

I took it for about a month and got severe stomach pains and diarrhea from it but my movement specialist said it would eventually stop but after I nearly didn’t make it to the bathroom at my grandson’s baseball game, I stopped taking it!

May 15
A MyParkinsonsTeam Member

I tried it and I got dyskskineasa really bad in my legs they were moving constantly and drove me crazy so I'm on prampexole 3 times a day

May 5
MyParkinsonsTeam

Great question! Entacapone (Comtan) is a COMT inhibitor, which is a type of add-on medication that works alongside your carbidopa/levodopa. It helps prevent levodopa from breaking down too quickly in your bloodstream, so more of it can reach your brain and work longer.

The main benefit is reducing "off" periods — those Show Full Answer

Great question! Entacapone (Comtan) is a COMT inhibitor, which is a type of add-on medication that works alongside your carbidopa/levodopa. It helps prevent levodopa from breaking down too quickly in your bloodstream, so more of it can reach your brain and work longer.

The main benefit is reducing "off" periods — those times when your medication seems to wear off and symptoms become more noticeable. However, it's worth knowing about some potential side effects to watch for:

- Dyskinesia (involuntary movements) — entacapone can increase this levodopa side effect
- Confusion or hallucinations
- Diarrhea
- Urine discoloration — often a reddish or brownish tint, which is harmless but can be surprising!

The good news is that entacapone is also available as a combination pill called Stalevo, which combines levodopa, carbidopa, and entacapone in one tablet — fewer pills to manage!

Always let your neurologist know if you notice any new or worsening symptoms after starting it.

May 4
A MyParkinsonsTeam Member

I started this medicine about a month ago. My husband and I decided to 'embrace the suck ' and try knowing that it would be a rough ride. It was. I woke up one day with horrendous pain...every bone and joint. The 3 little ear bones were not involved. The ultimate was taking a hot bath for the pain. It was then my poor husband got a cup of of the bath water to pour over my back. The screaming was insane. It was as though it was as though the water was acid. My husband was horrified.
My other issue is rage from 5 to 7 pm. That can be quite off-putting. Fortunately my husband is very detailed and has created a regimen of naps, alarms and other important protocols. Now I must say I am significantly clearer! I hadn't realized how dim the bulb had gotten.

May 25

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