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Real members of MyParkinsonsTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

What does it mean when your directed dosage CL has no discernible effect on your PD symptoms? Should you always increase your dose?

A MyParkinsonsTeam Member asked a question 💭
Chicago, IL
March 31
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A MyParkinsonsTeam Member

@A MyParkinsonsTeam Member, It could mean that you don't actually have Parkinson's, but possibly one or more Parkinsonisms which cause symptoms similar to Parkinson's, but are not missing the dopamine, the defining factor of Parkinson's Disease. Having the prescriptions not work could also mean that your doctor hasn't found just the right medication that works for you. Tell your doctor what is and isn't happening. That's the one who needs to decide what it means.

March 31
MyParkinsonsTeam

What does it mean when your carbidopa/levodopa (CL) doesn't seem to be working?

When your prescribed dose of carbidopa/levodopa has no noticeable effect on your symptoms, it could mean several things:

- Your Parkinson's may be progressing, and your brain has lost more dopamine-producing cells, making it harder to store Show Full Answer

What does it mean when your carbidopa/levodopa (CL) doesn't seem to be working?

When your prescribed dose of carbidopa/levodopa has no noticeable effect on your symptoms, it could mean several things:

- Your Parkinson's may be progressing, and your brain has lost more dopamine-producing cells, making it harder to store and use the medication effectively
- You might not be absorbing the medication well, possibly due to delayed gastric emptying (a common issue in Parkinson's where food stays in your stomach longer)
- The medication may be wearing off more quickly than before

Should you always increase your dose?

No, you shouldn't automatically increase your dose on your own. This is a critical conversation to have with your neurologist. As Parkinson's progresses, simply increasing the dose doesn't always help and can actually increase the risk of side effects.

Your doctor may need to:
- Adjust your medication timing rather than the dose
- Consider alternative treatment options
- Evaluate whether absorption issues are affecting the medication's effectiveness

Keep a detailed diary with dates, times, symptoms, and when you take your medications. This information will help your neurologist make the best adjustments for your specific situation. Remember, what works for one person may not work for another with Parkinson's.

March 31

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