Answering Lmj3964 question,

I've read some very positive Hungarian experiences who had DBS. I haven't met any of them personally, but I willing to.

The main statment, better to have it the early stage of Parkinson.

The reasons:
a.) the inrevention slow down the progress of desease and its better to start earlier.
b.) The side affects of medication are significantly amplified by the time.

I'm just thinking about to have this (DBS) intervention,
and collecting information the risks and benefits

There is a scientific portal (ELICIT) having a lot of relevant publications, and for the question ": How does the deep brain stimulation affects on the progress of Parkinson disease?" , the portal generated the report I share with you below.

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ELICIT

The whole original report can be reached the folowing link.
https://elicit.com/review/8c04270c-58b7-4c82-9c...

Title
Does deep brain stimulation slow disease progression more effectively compared to standard pharmacological interventions in patients with Parkinson's disease?
Research shows inconclusive results regarding DBS's ability to slow Parkinson's disease progression compared to standard pharmacological treatments.

Abstract
Deep brain stimulation (DBS) in Parkinson’s disease has been evaluated in 10 studies involving over 1,700 patients.
Randomized trials and systematic reviews report that, compared to pharmacological treatment, DBS yields marked improvements in motor symptoms. For example, one trial showed that 71% of DBS-treated patients achieved a ≥5‐point improvement on the Unified Parkinson’s Disease Rating Scale (UPDRS-III) versus 32% on medical therapy (p < 0.001), while another reported a mean UPDRS-III improvement of 19.6 points and a between‐group difference of –15.50 (p < 0.00001). A lower risk of worsening rest tremor was also noted (odds ratio 0.21, 95% CI 0.09 to 0.45, p < 0.001).
Key findings

Overall findings:
- DBS generally showed better outcomes in motor symptom progression and quality of life compared to pharmacological treatment.
- DBS was associated with reduced medication requirements in most studies that reported this outcome.
- DBS appeared to have a higher risk of complications, particularly in the short term, compared to pharmacological treatment.
- Long-term safety profiles were mixed, with some studies showing similar safety between DBS and pharmacological treatment, while others indicated a higher risk with DBS
- The lack of detailed information on medication-related complications in most studies limits our ability to make comprehensive comparisons of safety profiles.